TLA4/CT60 Polymorphism Is Not elevant in Susceptibility to Autoimmune nflammatory Intestinal Disorders
نویسندگان
چکیده
K ABSTRACT: The aim of this work was to investigate the possible influence of the recently described CT60 A/G dimorphism of the CTLA4 (cytotoxic T-lymphocyte antigen 4) gene in the susceptibility to two different autoimmune inflammatory intestinal disorders, inflammatory bowel disease (IBD) and celiac disease. We analyzed a case-control cohort composed of 528 Spanish patients with IBD (284 with Crohn disease and 244 with ulcerative colitis) and 454 unrelated healthy individuals, and additionally a group of 90 celiac disease families. CT60 genotyping was performed with a TaqMan 5= allelic discrimination assay. After comparing patients with IBD with the control population, we found no significant n
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تاریخ انتشار 2005